Essentially, PKA is responsible for all the cellular responses induced by cAMP second messenger system. It is also commonly known as the cAMP dependent A kinase, therefore it works through the cAMP signalling pathway. Protein Kinase A (PKA) is one of the member of family of enyzmes which is functionally dependent on the levels of cyclic-adenomonophopshate ( cAMP). This means that the protein can now phosphorylate other proteins by removing a phosphate from ATP, and adding it to a serine residue on the target protein which in turn leads to a cellular respons. This change means that the catalytic subunit becomes active and is no longer inhibited. When cAMP binds to a regulatory subunit a conformational change occurs. These subunits are inactive when cAMP is not bound. The molecule consists of two subunits, a regulatory subunit and a calalytic subunit. PKA is involved in signal-transduction pathways and phosphorylates proteins by adding a phosphate group. Protein Kinase A (PKA) is a protein that is dependent on cyclic AMP ( cAMP) and without it, is deactivated.
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