rickettsii would be the only tick-borne rickettsia conclusively associated with disease in humans in the Western Hemisphere. rickettsii, referred to as “ Dermacentroxenus rickettsii” at that time, was maintained by ticks and also described the fundamental histopathologic lesions of RMSF ( 365). Burt Wolbach provided definitive experimental evidence that R. Ricketts reported the role of the wood tick in the transmission of the causative agent, subsequently named Rickettsia rickettsii ( 283, 284, 365). Maxey reported the first clinical description of Rocky Mountain spotted fever (RMSF), the prototypical tick-borne rickettsiosis ( 198). These zoonoses are among the oldest known vector-borne diseases. Tick-borne rickettsioses are caused by obligate intracellular bacteria belonging to the spotted fever group (SFG) of the genus Rickettsia within the family Rickettsiaceae in the order Rickettsiales ( 276).
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